A woman and a baby are reported to be among the dead. Rescuers are searching through the rubble at the scene in Cinar district, Diyarbakir province.
The bomb was detonated at the entrance of the police complex, officials say. The blast also damaged nearby residential buildings.
The attackers then reportedly fired rockets at the headquarters.
Diyarbakir province has seen violent clashes between PKK separatists and the Turkish army in recent months.
Last year, the city of Diyarbakir and a number of other areas in the south-east were put under curfew as part of a security crackdown.
This followed a bomb blast that left 16 soldiers dead and a rebel ambush that killed 14 police officers - both incidents in the east.
No group has so far said it carried out the attack.
The bomb was detonated at the entrance of the police complex, officials say. The blast also damaged nearby residential buildings.
The attackers then reportedly fired rockets at the headquarters.
Diyarbakir province has seen violent clashes between PKK separatists and the Turkish army in recent months.
Last year, the city of Diyarbakir and a number of other areas in the south-east were put under curfew as part of a security crackdown.
This followed a bomb blast that left 16 soldiers dead and a rebel ambush that killed 14 police officers - both incidents in the east.
No group has so far said it carried out the attack.
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