The explosion rocked a checkpoint at Al Haram street in the Egyptian capital Cairo this morning.
All of the victims were police officers either in or near their car while four civilians were hurt when the device went off near a bin.
The attack, close to a government building in a middle class neighbourhood of Cairo, was the latest in a series of security incidents in Egypt often claimed by radical Islamists.
Security forces killed three gunmen on Tuesday in a raid on a hideout in southern Egypt used by what they described as an armed wing of the Muslim Brotherhood, which claimed responsibility in September for an assassination attempt on a senior prosecutor.
An Egyptian general was killed by militants on Nov. 4 near his home in North Sinai in an attack for which Islamic State claimed responsibility. He was the second military officer of his rank to be shot dead in as many weeks.
Hundreds of soldiers and police have been killed in an Islamist insurgency led by ISIS in the Sinai Peninsula.
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